New Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?

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dc.authorid0000-0003-3621-6658en_US
dc.authorid0000-0002-8559-2476en_US
dc.authorid0000-0003-3163-2345en_US
dc.authorid0000-0002-3364-7498en_US
dc.authorid0000-0001-9398-8908en_US
dc.authorid0000-0002-0991-2132en_US
dc.contributor.authorErdi, Fatih
dc.contributor.authorKaya, Bülent
dc.contributor.authorEsen, Hasan
dc.contributor.authorKarataş, Yaşar
dc.contributor.authorFındık, Sıddıka
dc.contributor.authorKeskin, Fatih
dc.contributor.authorFeyzioğlu, Bahadır
dc.contributor.authorKalkan, Erdal
dc.date.accessioned2020-01-18T21:02:49Z
dc.date.available2020-01-18T21:02:49Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Anabilim Dalıen_US
dc.description.abstractAIm: To evaluate and compare the expression of thioredoxin reductase 1 (TrxR1) in primary and secondary glioblastoma samples. mATERIAl and mEThODS: Surgically resected human glioblastoma samples from 40 patients who underwent surgery at our institution were extracted from their histopathological specimens and divided into three groups. Ten histopathologically regular cerebral tissue samples, acquired from the non-neoplastic portion of the specimens, were assigned as the control group. Twenty specimens that included tumoral tissue from each type of glioblastoma (WHO grade IV, primary and secondary) were assigned as the primary and secondary glioblastoma groups. TrxR1 expression was analyzed by using both quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry. Isocitrate dehydrogenase 1 (IDH1) mutation was analyzed by immunohistochemistry. Ki-67 proliferative index and apoptosis were also analyzed by immunohistochemistry. The differences between the groups were statistically compared and the correlation between these parameters was analyzed. RESulTS: The expressions of TrxR1 and Ki-67 values were significantly higher in primary glioblastoma. IDH1 mutation was significantly higher in secondary glioblastoma. TrxR1 expression was found to be highly correlated with the Ki-67 index. The apoptotic index was similar between primary and secondary glioblastoma. CONCluSION: This study showed a high TrxR1 expression in primary glioblastoma which could indicate a role of the Trx system in promoting the malignant progression by some complex processes.en_US
dc.identifier.citationErdi, F., Kaya, B., Esen, H., Karatas, Y., Findik, S., Keskin, F., Feyzioglu, B., Kalkan, E. (2018). New clues in the malignant progression of glioblastoma: can thioredoxin system play a role?. Turkish Neurosurgery, 28, 1, 7-12.en_US
dc.identifier.doi10.5137/1019-5149.JTN.18991-16.2en_US
dc.identifier.endpage12en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage7en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpjeE16SXpNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1300
dc.identifier.volume28en_US
dc.identifier.wosWOS:000423394400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectThioredoxin Reductase 1en_US
dc.subjectIsocitrate Dehydrogenase 1en_US
dc.subjectGlioblastomaen_US
dc.subjectPrimaryen_US
dc.subjectSecondaryen_US
dc.subjectMutationen_US
dc.titleNew Clues in the Malignant Progression of Glioblastoma: Can the Thioredoxin System Play a Role?en_US
dc.typeArticleen_US

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