Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats

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dc.authoridTamer Baysal: 0000-0001-6145-1831
dc.authoridAyşe Saide Şahin: 0000-0001-6432-5822
dc.authoridBurak Cem Soner: 0000-0002-3712-3210
dc.contributor.authorBaysal, Tamer
dc.contributor.authorŞahin, Ayşe Saide
dc.contributor.authorAlp, Hayrullah
dc.contributor.authorSoner, Burak Cem
dc.date.accessioned2020-01-18T21:02:56Z
dc.date.available2020-01-18T21:02:56Z
dc.date.issued2015
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Anabilim Dalıen_US
dc.description.abstractObjective: Digitalis preparations are commonly used by children and adults with heart diseases worldwide, although excessive doses may cause cardiac effects. The aim of the study is to evaluate the antiarrhythmic effect of Crataegus oxyacantha extract on digoxin-induced arrhythmias in anesthetized Wistar rats. Methods: Control and experimental groups were evaluated for arrhythmias induced by digoxin. Fifteen rats (7 as controls and 8 as the experimental group) were included in the study. The dry fruits of 100 mg Crataegus oxyacantha were extracted by percolation method. Digoxin, at a dose of 40 ?g/kg/min, was infused to form the arrhythmias in all rats. Simultaneously, the extract was infused into the experimental group, while 0.9% NaCl was infused into control group. Electrocardiographic QRS prolongation and arterial blood pressure changes were analyzed.Results: The experimental group lived longer (62.13 2.20 min) than the controls (p0.002). On the other hand, the time to beginning of QRS prolongation did not differ between the two groups (p0.812). Bradycardia was significant in the control group (288.01 10.54 beat/min and p0.01). The maximum QRS duration was observed in the control group during the digoxin and 0.9% NaCl infusion period (53.29 3.99 ms and p0.001). Also, the durations of atrial and ventricular arrhythmias were shorter in the experimental group. However, arterial blood pressure dipping was significant in the experimental group (23.67 10.89 mm Hg and p0.001).Conclusion: Crataegus oxyacantha alcoholic extract produced an antiarrhythmic effect that was induced by digoxin in Wistar rats. However, in the clinical use of this extract, the hypotensive effect should be considered. Also, the alcoholic extract of Crataegus oxyacantha may be an alternative treatment medication for arrhythmias induced by digoxin toxicity in humans.en_US
dc.identifier.citationBaysal, T., Şahin, A. S., Alp, H., Soner, B. C. (2015). Protective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in rats. The Anatolian Journal of Cardiology, 15, 12, 970-975.
dc.identifier.doi10.5152/akd.2014.5869en_US
dc.identifier.endpage975en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage970en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TVRrNU5qQTJOZz09/protective-effects-of-hawthorn-crataegus-oxyacantha-extract-against-digoxin-induced-arrhythmias-in-rats
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1376
dc.identifier.volume15en_US
dc.identifier.wosWOS:000366597000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.relation.ispartofThe Anatolian Journal of Cardiologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrataegus oxyacanthaen_US
dc.subjectDigoxinen_US
dc.subjectArrhythmiaen_US
dc.subjectAntiarrhythmic effecten_US
dc.subjectHypotensionen_US
dc.titleProtective effects of Hawthorn (Crataegus oxyacantha) extract against digoxin-induced arrhythmias in ratsen_US
dc.typeArticleen_US

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