Effects of adjuvant therapy on body composition measurements in women with early breast cancer

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dc.authoridMelek Karakurt Eryılmaz: 0000-0003-2597-593
dc.authoridMurat Araz: 0000-0002-4632-9501
dc.authoridMehmet Emre Atabek: 0000-0002-2242-9401
dc.authoridMehmet Artaç: 0000-0003-2335-3354
dc.contributor.authorEryılmaz, Melek Karakurt
dc.contributor.authorKaraağaç, Mustafa
dc.contributor.authorAraz, Murat
dc.contributor.authorAtabek, Mehmet Emre
dc.contributor.authorArtaç, Mehmet
dc.date.accessioned2020-01-18T21:03:17Z
dc.date.available2020-01-18T21:03:17Z
dc.date.issued2019
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Anabilim Dalıen_US
dc.description.abstractAim: This study aimed to determine the effects of adjuvant therapy on body mass index (BMI) and body fat (BF) measurements inwomen with early-stage breast cancer (ESBC).Material and Methods: We prospectively evaluated BMI and BF measurements including trunk fat mass kilograms (kg), trunk fatmass (%) and total body fat (%) on a bioelectric impedance analyzer in 29 women with stages I-III breast cancer. All of the patientsreceived anthracycline-based adjuvant chemotherapy (ACT). Six patients were hormone receptor (HR)-negative. Twenty-threepatients were HR-positive and received adjuvant endocrine therapy (AET) following ACT. Eleven HR-positive postmenopausalpatients were treated with an aromatase inhibitor (AI), and the remaining twelve HR-positive premenopausal patients were treatedwith tamoxifen (TMX). A total of 3 measurements were performed in the beginning of chemotherapy, at 6th, and 12th months.Results: Although the BMI was significantly increased, there was no significant change in the BF during chemotherapy in patientsreceiving only ACT. Both BMI and BF measurements were significantly increased in premenopausal patients receiving TMX afterACT. However, no significant change was observed in BMI and BF measurements in postmenopausal patients receiving AI after ACT.Conclusions: ACT increased both BMI and BF measurements in patients with HR-positive premenopausal ESBC. Treatment withTMX or AI after ACT did not enhance the changes due to chemotherapy on body composition. Therefore, especially patients withHR-positive premenopausal ESBC should be careful not to gain weight during ACT.en_US
dc.identifier.citationEryılmaz, M. K., Karaağaç, M., Araz, M., Atabek, M. E., Artaç, M. (2019). Effects of adjuvant therapy on body composition measurements in women with early breast cancer. Annals of Medical Research, 26, 9, 2039-2044.
dc.identifier.doi10.5455/annalsmedres.2019.04.190en_US
dc.identifier.endpage2044en_US
dc.identifier.issn2636-7688en_US
dc.identifier.issn2636-7688en_US
dc.identifier.issue9en_US
dc.identifier.startpage2039en_US
dc.identifier.urihttps://dx.doi.org/10.5455/annalsmedres.2019.04.190
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFNE5UazFOUT09/effects-of-adjuvant-therapy-on-body-composition-measurements-in-women-with-early-breast-cancer
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1518
dc.identifier.volume26en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of Medical Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEarly breast canceren_US
dc.subjectAdjuvant therapyen_US
dc.subjectBody mass indexen_US
dc.subjectBody fat measurementsen_US
dc.titleEffects of adjuvant therapy on body composition measurements in women with early breast canceren_US
dc.typeArticleen_US

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