Effects of Different Drug Treatments on The Proliferation of Human Ovarian Carcinoma Cell Line Mdah-2774
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite thathas nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single andcombined applications in monolayers of the MDAH-2774 human ovarian cancer cell line.Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dyeexclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h.Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cellcultures (P 0.05). All combination groups showed similar effects that were mainly more effective in respect to single usage of resveratroland gemcitabine in monolayer cell cultures.Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 humanovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction ofcell structure were observed.
Açıklama
WOS:000431261100036
PubMed ID:29714468
PubMed ID:29714468
Anahtar Kelimeler
Ovarian cancer, Gemcitabine, Paracetamol, Resveratrol
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
48
Sayı
2
Künye
Soner, B. C., Ayla, S., Bilir, A., Ertürkoğlu, S., Tanrıverdi, G., Sofuoğlu, K., Öktem, G., Ghisolfi, L. (2018). Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences, 48, 2, 441-448.
