Effects of Different Drug Treatments on The Proliferation of Human Ovarian Carcinoma Cell Line Mdah-2774

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dc.authoridBurak Cem Soner: 0000-0002-3712-3210en_US
dc.contributor.authorAyla, Şule
dc.contributor.authorBilir, Ayhan
dc.contributor.authorErtürkoğlu, Şenol
dc.contributor.authorTanrıverdi, Gamze
dc.contributor.authorSoner, Burak Cem
dc.contributor.authorSofuoğlu, Kenan
dc.contributor.authorGhisolfi, Laura
dc.contributor.authorÖktem, Gülperi
dc.date.accessioned2020-01-18T21:04:36Z
dc.date.available2020-01-18T21:04:36Z
dc.date.issued2018
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Anabilim Dalıen_US
dc.descriptionWOS:000431261100036en_US
dc.descriptionPubMed ID:29714468en_US
dc.description.abstractBackground/aim: In this study, the effects of resveratrol as a natural polyphenol compound, gemcitabine as an antimetabolite thathas nucleoside structure analogous to deoxycytidine, and para-aminophenol-derived paracetamol were investigated with single andcombined applications in monolayers of the MDAH-2774 human ovarian cancer cell line.Materials and methods: Drugs were evaluated in cell culture with respect to cell proliferation, cell cytotoxicity (trypan blue dyeexclusion test), synthesis phase of cell cycle, and cell structure in 24, 48, 72, and 96 h.Result: Resveratrol and gemcitabine diminished both cell proliferation and cell cycle synthesis phase indication in monolayer cellcultures (P 0.05). All combination groups showed similar effects that were mainly more effective in respect to single usage of resveratroland gemcitabine in monolayer cell cultures.Conclusion: The effects of gemcitabine, resveratrol, and paracetamol were investigated in monolayers of the MDAH-2774 humanovarian cancer cell line and a decrease in cell number in cell cycle synthesis phase, prevention of cell proliferation, and destruction ofcell structure were observed.en_US
dc.identifier.citationSoner, B. C., Ayla, S., Bilir, A., Ertürkoğlu, S., Tanrıverdi, G., Sofuoğlu, K., Öktem, G., Ghisolfi, L. (2018). Effects of different drug treatments on the proliferation of human ovarian carcinoma cell line MDAH-2774. Turkish Journal of Medical Sciences, 48, 2, 441-448.en_US
dc.identifier.doi10.3906/sag-1507-193en_US
dc.identifier.endpage448en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue2en_US
dc.identifier.pmid29714468en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage441en_US
dc.identifier.urihttps://dx.doi.org/10.3906/sag-1507-193
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprNE56YzNOdz09/effects-of-different-drug-treatments-on-the-proliferation-of-human-ovarian-carcinoma-cell-line-mdah-2774
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1871
dc.identifier.volume48en_US
dc.identifier.wosWOS:000431261100036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOvarian canceren_US
dc.subjectGemcitabineen_US
dc.subjectParacetamolen_US
dc.subjectResveratrolen_US
dc.titleEffects of Different Drug Treatments on The Proliferation of Human Ovarian Carcinoma Cell Line Mdah-2774en_US
dc.typeArticleen_US

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