Splenic artery embolization with Ankaferd blood stopper in a sheep model
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
PURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%-95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the shortterm. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent.
Açıklama
WOS:000379846300009
PubMed ID:27306661
PubMed ID:27306661
Anahtar Kelimeler
Kaynak
Diagnostic and Interventional Radiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
22
Sayı
4
Künye
Koç, O., Acar, K., Toy, H., Güler, İ., Özbek, S., Sarıtaş, K., Erdem, T. B., Küçükapan, A., Solak, Y., Gaipov, A., Haznedaroğlu, İ. C. (2016). Splenic artery embolization with Ankaferd blood stopper in a sheep model. Diagnostic and Interventional Radiology (ankara, Turkey), 22, 4, 354-357.
