Splenic artery embolization with Ankaferd blood stopper in a sheep model

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dc.authoridOman Koç: 0000-0003-2123-4589en_US
dc.authoridTuba Bera Sarıtaş: 0000-0002-3206-6851en_US
dc.contributor.authorKoç, Osman
dc.contributor.authorAcar, Kadir
dc.contributor.authorOrhan, Özbek
dc.contributor.authorGüler, İbrahim
dc.contributor.authorSarıtaş, Kadir
dc.contributor.authorErdem, Tuba Berra
dc.contributor.authorToy, Hatice
dc.contributor.authorGaipov, Abduzhappar
dc.contributor.authorHaznedaroğlu, İbrahim C.
dc.date.accessioned2020-01-18T21:03:00Z
dc.date.available2020-01-18T21:03:00Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000379846300009en_US
dc.descriptionPubMed ID:27306661en_US
dc.description.abstractPURPOSE Splenic artery embolization is a minimally invasive therapeutic procedure utilized in a number of disorders. Ankaferd blood stopper (ABS) is a novel hemostatic agent with a new mechanism of action independent of clotting factors. We aimed to investigate the safety and efficiency of ABS for splenic artery embolization in a sheep model. METHODS Seven adult female sheep were included in the study. Selective celiac angiography was performed using a 5F diagnostic catheter and then a 2.7F hydrophilic coating microcatheter was advanced coaxially to the distal part of the main splenic artery. Under fluoroscopic guidance, 6 mL mixture composed of half-and-half ABS and contrast agent was slowly injected. Fluoroscopy was used to observe the deceleration and stagnation of the flow. Control celiac angiograms were obtained immediately after the embolization. After the procedure, the animals were observed for one day and then sacrificed with intravenous sodium thiopental. RESULTS Technical success rate was 100%. None of the animals died or experienced a major systemic adverse event during the procedure. All of the spleens appeared dark on macroscopic examination due to excessive thrombosis. Microscopically, the majority of the splenic sinusoids (90%-95%) were necrotic. CONCLUSION In our study, splenic artery embolization by ABS was found to be safe and effective in the shortterm. Further studies are needed to better understand the embolizing potential of this novel hemostatic agent.en_US
dc.identifier.citationKoç, O., Acar, K., Toy, H., Güler, İ., Özbek, S., Sarıtaş, K., Erdem, T. B., Küçükapan, A., Solak, Y., Gaipov, A., Haznedaroğlu, İ. C. (2016). Splenic artery embolization with Ankaferd blood stopper in a sheep model. Diagnostic and Interventional Radiology (ankara, Turkey), 22, 4, 354-357.en_US
dc.identifier.doi10.5152/dir.2015.15382en_US
dc.identifier.endpage357en_US
dc.identifier.issn1305-3612en_US
dc.identifier.issue4en_US
dc.identifier.pmid27306661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage354en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpJd09EYzVPUT09/splenic-artery-embolization-with-ankaferd-blood-stopper-in-a-sheep-model
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1404
dc.identifier.volume22en_US
dc.identifier.wosWOS:000379846300009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofDiagnostic and Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSplenic artery embolization with Ankaferd blood stopper in a sheep modelen_US
dc.typeArticleen_US

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